Safe Surf Rated - www.safesurf.com Back To Home Page Family Friendly Site - www.familyfriendlysites.com
About
Bradford
  HIV/AIDS
Articles
  Alternative
Therapies
  HIV/AIDS
Videos
  HIV/AIDS
Links
  HIV/AIDS
News

Introduction:
Positively Positive
- Living with HIV
  Out
About
HIV
  Resume/
Curriculum Vitae:
HIV / AIDS Involvements
  Biography   HIV/AIDS
News Archive
HIV and AIDS News Bradford McIntyre
   
AIDS Awareness Red Ribbon


Harnessing immune cells' adaptability to design an effective HIV vaccine

21-Mar-2013 - In infected individuals, HIV mutates rapidly to escape recognition by immune cells. This process of continuous evolution is the main obstacle to natural immunity and the development of an effective vaccine. A new study published by Cell Press in the March 21 issue of the journal Immunity reveals that the immune system has the capacity to adapt such that it can recognize mutations in HIV. The findings suggest that our immune cells' adaptability could be harnessed to help in the fight against AIDS.

An international collaboration between research groups in France, England, Japan, and Australia discovered that immune cells from certain infected individuals were able to recognize HIV mutants. Researchers found that the immune cells' ability to recognize such mutant forms of the virus was associated with a protective response against HIV. This discovery begs the question: if mutant HIV can be recognized by immune cells, how then does HIV often escape immune detection? The researchers explain that the answer lies in HIV's ability to conceal itself from immune surveillance altogether. It does so by blocking infected cells from breaking down its viral particles and from then displaying them on the cells' surface to alert the immune system.

"Using a spectrum of advanced immune profiling techniques, our work illustrates the sophisticated mechanisms that underlie the continuous competition, or 'molecular arms race,' between immune cells and HIV," says senior author Dr. Victor Appay, of Hôpital Pitié-Salpêtrière in Paris. "Overall, our study reveals the intricacies of immune cell efficacy against HIV."

Although immune cells not be able to recognize every mutant HIV, a vaccine that stimulates immune cells that recognize certain key mutant forms of the virus may be effective against viral infection and the development of AIDS.

###

Immunity, Ladell et al.: "A molecular basis for the control of pre-immune escape variants by HIV-specific CD8+ T-cells."

 

Contact:
Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Source: http://www.eurekalert.org/pub_releases/2013-03/cp-hic031313.php


For more HIV and AIDS News visit...

Positively Positive - Living with HIV/AIDS:
HIV/AIDS News


...positive attitudes are not simply 'moods'

Site Map

Contact Bradford McIntyre.

Web Design by Trevor Uksik

Copyright © 2003-2017 Bradford McIntyre. All rights reserved.

DESIGNED TO CREATE HIV & AIDS AWARENESS