Scale-up of HIV treatment in rural South Africa dramatically increases adult life expectancy
February 21, 2013 - Boston, MA - The large antiretroviral treatment (ART) scale-up in a rural community in
KwaZulu-Natal, South Africa, has led to a rapid and dramatic increase in population adult life expectancy-a gain of 11.3 years
over eight calendar years (2004-2011)-and the benefit of providing ART far outweighs the cost, according to new research from
Harvard School of Public Health (HSPH).
While previous studies have shown that ART significantly improves survival in clinical cohorts of HIV patients receiving ART,
this is the first study to directly measure the full population-level impact of a public-sector ART program on adult life
"This is one of the most rapid life expectancy gains observed in the history of public health" said Till Bärnighausen,
associate professor of global health in the HSPH Department of Global Health and Population and senior author of the
study, which was published online in Science on February 21, 2013.
"The public-sector scale-up of ART has largely reversed the decline in adult life expectancy due to HIV that
occurred in the 1990s and early 2000s in the region," said Jacob Bor, the lead author of the study and an
HSPH doctoral candidate in the Department of Global Health and Population.
The researchers measured dates of death using data from a large community-based population surveillance system that included
information on all births and deaths among more than 100,000 people living in rural KwaZulu-Natal, in South Africa, between
2000 and 2011. Data were collected twice a year, through household surveys, by the Africa Centre for Health and
Population Studies at the University of KwaZulu-Natal.
In 2003, the year before ART became widely available to people in KwaZulu-Natal, adult life expectancy was 49.2 years; by 2011,
it had increased to 60.5 years. Both men and women experienced large gains in life expectancy-9 years and 13.3 years,
respectively. Using cause of death data, the researchers calculated life expectancy among people dying of causes
other than HIV. They found that the observed life expectancy gains were almost exclusively due to changes in
HIV-related mortality, with no changes in mortality rates from other causes.
"Many people have been worried that the ART scale-up, which is a massive public health intervention, would negatively affect
populations who do not suffer from HIV but need care for other diseases. We do not find any evidence to support this worry,"
Previous studies have attempted to predict the effects and costs of ART programs. Such predictive models, however, require
many assumptions about ART effects and costs, which may not hold in reality. This study compared observed changes in
adult survival at the population level with the costs of providing ART in this community between 2004 and 2011 to
empirically establish the cost-effectiveness of past ART delivery. The ART cost-effectiveness ratio was $1593
per life year saved, that is, less than a quarter of South Africa's 2011 per-capita gross national
income (GNI) needed to be invested in the ART scale-up to save one life year.
"Interventions that cost less than per-capita GNI per life year saved are usually considered highly cost-effective," said
Bärnighausen. "We find that a real-life public-sector ART program in rural Africa is a very worthwhile investment, despite
the fact that treatment failures rates in this program are high because of problems with retention and medication
adherence. This information is important for governments and donors debating future investments for ART programs."
Bärnighausen was co-author on another study, also published online in Science on February 21, 2013, that provides the first
empirical evidence that the risk of acquiring HIV among HIV-uninfected individuals in a typical rural population with high
HIV prevalence in southern Africa declines significantly with ART coverage in their surrounding communities. For this
study, researchers used data from one of Africa's largest population-based HIV surveillance systems to follow up
with almost 17,000 individuals who were HIV-uninfected at baseline, to observe individual HIV infections from 2004 to 2011.
Support for the two studies came from the Wellcome Trust and National Institutes of Health grants R01 HD058482-01 and
"Increases in Adult Life Expectancy in Rural South Africa: Valuing the Scale-Up of HIV Treatment," Jacob Bor, Abraham J. Herbst,
Marie-Louise Newell, Till Bärnighausen, Science, online February 21, 2013
"High Coverage of ART Associated with Decline in Risk of HIV Acquisition in Rural KwaZulu-Natal, South Africa," Frank Tanser,
Till Bärnighausen, Erofili Grapsa, Jaffer Zaidi, Marie-Louise Newell, Science, online February 21, 2013
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Source: Harvard School of Public Health
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