Undetectable blood viral load and HIV transmission risk: results of a systematic review
Mar 7, 2013
The sexual transmission of HIV occurs after an exposure to fluids that contain HIV, such
as semen and fluids from the vagina and rectum. Research shows that a higher amount of HIV (viral load)
in these fluids increases the risk of HIV transmission and that a lower viral load decreases the
Treatment, viral load and HIV transmission
The viral load in the blood of a person living with HIV is measured to monitor the success of
antiretroviral therapy (also called ART, HAART or cART). Successful HIV treatment can reduce
the viral load in the blood (and other bodily fluids) to undetectable levels and thereby
reduce the risk of sexual HIV transmission. In fact, a research study known
as HPTN 052 found that the risk of HIV transmission among heterosexual serodiscordant couples was 96% lower when the HIV-positive partner was on treatment. 2 (In serodiscordant couples, one partner is HIV-positive and the other is HIV-negative.)
Undetectable viral load does not mean that there is no virus, but rather that the amount of HIV in a bodily
fluid is below a level that tests can detect. (Tests used in some places, such as Canada, cannot detect HIV
if there are less than 40 copies of HIV per ml of blood, while tests used in other parts of the world have
higher limits of detection.)
Also, not all people living with HIV who take HIV treatment and have an undetectable viral load in the
blood also have an undetectable viral load in their other bodily fluids. Research suggests that of those
people living with HIV who have an undetectable blood viral load, 5 to 48% can have detectable virus
in their semen, vaginal fluid and rectal fluid. 3 , 4 , 5
Although previous research has demonstrated that treatment can reduce the risk of HIV transmission in
heterosexual couples, it is unclear exactly what the HIV transmission risk is when a person's blood
viral load is undetectable. A recent systematic
review 6 of the literature was conducted by Dr. Mona Loutfy, one of Canada's leading infectious disease specialists, and colleagues to gain a better understanding of this risk.
The authors searched for published studies that followed serodiscordant heterosexual or same-sex couples
over time. The main purpose of the review was to find studies that met the following criteria:
- the HIV-positive partner was on antiretroviral treatment
- the number of HIV infections in the HIV-negative partner was recorded
- if HIV transmission occurred, the HIV-positive partner's blood viral load was measured close to the time of transmission
The authors identified only three studies that fit all of their criteria. These studies followed a total
of 222 heterosexual couples from Brazil, Spain and Uganda.
An additional three studies were identified that fit all of their criteria but did not measure the viral
load of the HIV-positive partner near the time of HIV transmission, including the HPTN 052 randomized
controlled trial. These studies enrolled a total of 1,304 couples on treatment.
Overall, these six studies contained 2,975 person-years follow up of treated couples. This is the equivalent of following 2,975 couples for one year. The vast majority of these couples were heterosexual and only a small number were same-sex couples (3% of the couples in the HPTN 052 study were same-sex).
Number of HIV transmissions and HIV transmission risk
In the three studies where viral load was measured, no HIV transmissions occurred among couples where the
HIV-positive partner was on treatment and the viral load was undetectable.
In the additional three studies, for which viral load was not measured, a total of four transmissions
occurred. However, it is not known if the viral load of the HIV-positive partner was detectable or
undetectable at the time of transmission. All of these HIV transmissions occurred shortly after
the HIV-positive partner started treatment; therefore, the viral load was likely declining
but still detectable when transmission occurred.
In these six studies, the definition of undetectable viral load ranged from less than 50 copies per ml
to less than 500.
The lack of HIV transmissions in these studies does not mean there is no risk of HIV transmission when
the viral load is undetectable. Using data from all six studies (but excluding the four HIV
transmissions that occurred in the additional three studies), the authors calculated t
hat when the viral load is undetectable, there may be a 1% risk of HIV transmission
per 10 years of relationship and sexual activity.
Limitations of the study findings
There are several factors-other than viral load-that can influence the risk of HIV transmission between
serodiscordant couples and may partly explain the lack of HIV transmissions observed in this review. As
a result, the authors of the systematic review listed several caveats to their findings, including
the lack of data on:
1. Extent of condom use
Condoms are an effective method of preventing the transmission of HIV and many STIs and couples in these
studies may have been using condoms often. For example, in the HPTN 052 study, 96% of the couples reported
using condoms every time they had sex. Although people often say they use condoms more than they
actually do, condom use may have played an important role in keeping the number of HIV
transmissions low in these studies.
2. Same-sex couples and type of sexual intercourse
The vast majority of the couples enrolled in the studies were heterosexual and were (likely) having mostly
vaginal sex. Therefore, it is unclear how much these findings apply to same-sex couples and other couples
who mostly have anal sex. Some researchers think the risk of HIV transmission when undetectable may be
higher for anal sex compared to vaginal sex.
3. Rates of sexually transmitted infections (STIs)
STIs are known to increase the risk of HIV-positive people transmitting HIV and HIV-negative partners
becoming infected. STIs may increase the risk of HIV transmission even when a person's viral load is
undetectable. However, most of the studies reviewed did not provide data on STIs other than HIV;
therefore, the review could not evaluate their impact.
In general, the risk of having STIs is lower among stable heterosexual couples (particularly those
who are monogamous) than among people in casual relationships. Also, in some studies, such as the
HPTN 052 study, participants were provided with regular STI testing and treatment which can
help to further reduce the rate of STIs. A low number of STIs among couples in these
studies may have decreased the risk of HIV transmission.
This systematic review supports previous research showing that treatment can significantly reduce the
risk of HIV transmission among heterosexual couples. The authors concluded: "Our findings suggest
minimal risk of sexual HIV transmission for heterosexual serodiscordant couples when the
HIV-positive partner has full viral suppression on cART with caveats regarding
information on sexual intercourse type, STIs, and condom use. These findings
have implications when counseling heterosexual serodiscordant couples on
sexual and reproductive health."
Research is ongoing to gain a better understanding of the risk of HIV transmission (a) when the
HIV-positive partner's viral load is undetectable and condoms
are not used and (b) in same-sex serodiscordant
couples where the HIV-positive partner is taking ART.
Understanding Risk: A
- 1. Baeten JM, Kahle E, Lingappa JR et al. Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Science Translational Medicine . 2011 Apr 6;3(77):77ra29.
- 2. Cohen MS, Chen YQ, McCauley M et al. Prevention of HIV-1 infection with early antiretroviral therapy. New England Journal of Medicine . 2011 Aug 11;365(6):493-505.
- 3. Marcelin A-G, Tubiana R, Lambert-Niclot S et al. Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma. AIDS . 2008 Aug 20;22(13):1677-9.
- 4. Sheth PM, Yi TJ, Kovacs C et al. Mucosal correlates of isolated HIV semen shedding during effective antiretroviral therapy. Mucosal Immunology . 2012 May;5(3):248-57.
- 5. Sheth PM, Kovacs C, Kemal KS et al. Persistent HIV RNA shedding in semen despite effective antiretroviral therapy. AIDS . 2009 Sep 24;23(15):2050-4.
- 6. Loutfy MR, Wu W, Letchumanan M et al. Systematic Review of HIV Transmission between Heterosexual Serodiscordant Couples where the HIV-Positive Partner Is Fully Suppressed on Antiretroviral Therapy. PLoS ONE . 2013 Feb 13;8(2):e55747.
From Canadian AIDS Treatment Information Exchange (CATIE). For more information visit CATIE's Information Network
Source: CATIE: CANADIAN AIDS TREATMENT INFORMATION EXCHANGE
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