UCSF funded to provide PrEP consultations for clinicians
The UCSF Clinician Consultation Center at SFGH has been funded by the Centers for Disease Control and Prevention to provide a PrEPline, a telephone consultation service that gives expert guidance to health-care providers across the nation
29-Sep-2014 - The UCSF Clinician Consultation Center at San Francisco General Hospital and Trauma Center has been funded
by the Centers for Disease Control and Prevention (CDC) to provide a PrEPline, a telephone consultation service that gives expert guidance
to healthcare providers across the nation who prescribe antiretroviral medications to HIV uninfected
individuals to prevent HIV.
The intervention, commonly known as PrEP (pre-exposure prophylaxis) involves the daily use of an existing anti-HIV medication-a single
pill, two-drug combination of tenofovir and emtricitabine-to prevent HIV infection in adults at high risk. The Food and Drug
Administration approved the new indication in 2012, and earlier this year, the U.S. Public Health Service issued the first
comprehensive clinical guidelines for PrEP.
"Many of the clinicians prescribing PrEP will have had limited experience prescribing antiretroviral drugs. We will be guiding these
clinicians throughout the country as they work through decisions about who might benefit from PrEP as well as who is not appropriate
for receiving PrEP, including helping with identifying patients' risk," said the Center's director, Ron Goldschmidt, MD, UCSF
professor of family and community medicine at San Francisco General Hospital and Trauma Center (SFGH).
"In addition, we will be assisting clinicians in evaluating patients' ability to take PrEP regularly since missed doses can negate the
benefits of PrEP. We'll also be reminding clinicians to encourage other standard prevention methods, like using condoms, along with PrEP."
The Centers for Disease Control and Prevention has awarded $175,000 dollars in the first year of the grant to the UCSF Clinician
Consultation Center at SFGH, which will run the phone-based consultation service for clinicians with questions about PrEP.
"We also will be advising healthcare providers on how to give PrEP safely when it's indicated. Individuals on PrEP need an HIV test
to make sure they are uninfected before starting. Otherwise drug resistance could emerge in those with a pre-existing HIV infection.
And in a small percentage of patients, some side effects could be serious, so testing to monitor potential side effects as well
as other sexually transmitted infections is an important part of safely giving PrEP. We'll also provide guidance on stopping
PrEP safely when it's time to stop," added Goldschmidt.
So far, use of PrEP by individuals at risk of becoming infected with HIV has risen slowly following FDA approval. The manufacturer of
the only medication approved for PrEP to date estimated that only 1,774 prescriptions of the drug were filled for this indication
through May of 2013.
"We think that while the use of PrEP by individuals at high risk for HIV is accelerating, it has been hampered by barriers to access.
One significant barrier reported by many community members has been difficulties in getting their clinicians to prescribe PrEP when
they've asked for it. A major reason is many caregivers' lack of knowledge about and experience in prescribing PrEP. People who
are not HIV positive are seen by variety of providers including primary care doctors and ob/gyns. The new PrEP Warmline by
the Clinician Consultation Center addresses a large unmet need and will be a tremendous resource to help doctors safely
prescribe medications that many patients need to avoid HIV infection," said Dana Van Gorder, executive director of
Project Inform, one of the nation's leading HIV/AIDS advocacy agencies.
The UCSF Clinician Consultation Center at SFGH has provided nearly 400,000 telephone and online consultations with clinicians on preventing
and managing HIV/AIDS for more than twenty years. The services are provided by practicing physicians, nurses and pharmacists online and
via dedicated phone lines for HIV/AIDS care consultation, post-exposure prophylaxis (PEP) consultation, and perinatal HIV
consultation. The Center is funded through government support, primarily by the US Health Resources and Services
Administration AIDS Education and Training Centers and the CDC, and receives no support from pharmaceutical companies.
The UCSF Clinician Consultation Center at SFGH is affiliated with the AIDS Research Institute (ARI) at UCSF, which houses hundreds of
scientists and dozens of programs throughout UCSF and affiliated labs and institutions, making ARI one of the largest AIDS research
entities in the world. UCSF ranks #1 among medical schools in the U.S. for its AIDS programs according to US News & World
Report, as it has every year since the category was created in 2001.
UCSF is the nation's leading university exclusively focused on health. Now celebrating the 150th anniversary of its founding as a medical
college, UCSF is dedicated to transforming health worldwide through advanced biomedical research, graduate-level education in the life
sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine,
nursing and pharmacy; a graduate division with world-renowned programs in the biological sciences, a preeminent biomedical
research enterprise and two top-tier hospitals, UCSF Medical Center and UCSF Benioff Children's Hospital San Francisco.
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