New Rochelle, NY, October 6, - Measurable
changes in brain function and communication between brain regions may be a consequence of virus-induced injury during the early
stages of human immunodeficiency virus (HIV) infection. These abnormalities and their implications in disease prognosis are
detailed in an article in the groundbreaking new neuroscience journal Brain Connectivity , a
bimonthly peer-reviewed journal published by Mary Ann Liebert, Inc .
Diminished cognitive function will develop in about half of individuals infected with HIV, which may include
deficits in memory, attention, psychomotor capabilities, or verbal fluency. Evidence of cognitive decline in HIV infection has
implications for prognosis, reduced survival time, and increased risk of death.
Xue Wang and colleagues from Northwestern University (Chicago and Evanston, IL) and North Shore University
Health System (Evanston), used functional magnetic resonance imaging (fMRI) to obtain blood-oxygen-level-dependent measurements in
multiple brain regions that yield information on resting-state brain connectivity. They compared the measurements collected in
HIV-infected (less than 1 year) and healthy subjects. The authors report "prominent changes" between the two groups in the
functional connectivity of visual networks, which have a role in visuo-motor coordination. Based on these findings,
they conclude that functional connectivity measurements may be a useful, noninvasive tool for identifying
neurological involvement and central nervous system injury early in the course of HIV infection. The
findings from the NIH-funded Chicago Early HIV Infection Study are presented in the article,
"Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection."
"These findings indicate that changes in brain function are occurring very early in HIV infection, and
subclinical alterations in functional connectivity may reflect vulnerability to cognitive decline," says Ann Ragin, PhD, Principal
Investigator and Research Professor, Northwestern University Medical School, Chicago, IL.
"Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection" is available
free online for the next week at www.liebertpub.com/brain
Brain Connectivity is the journal of record for researchers and clinicians interested in all aspects of brain
connectivity. The Journal is under the leadership of founding and Co-Editors-in-Chief Christopher Pawela, PhD, assistant professor at
the Medical College of Wisconsin, and Bharat Biswal, PhD, associate professor at the University of Medicine and Dentistry of New
Jersey. The Journal includes original peer-reviewed papers, review articles, point-counterpoint discussions on controversies in
the field, and a product/technology review section. To ensure that scientific findings are rapidly disseminated, articles are
published Instant Online within 72 hours of acceptance, with fully typeset, fast-track publication within 4 weeks.
Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative medical and
biomedical peer-reviewed journals, including Journal of Neurotrauma and AIDS Research and Human Retroviruses . Its
biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the
industry's most widely read publication worldwide. A complete list of the firm's 70 journals, newsmagazines, and books is
available at www.liebertpub.com
Mary Ann Liebert, Inc. 140 Huguenot Street, New Rochelle, NY 10801-5215 www.liebertpub.com
Phone (914) 740-2100 (800) M-LIEBERT Fax (914) 740-2101
Contact: Julia Chapman
Mary Ann Liebert, Inc./Genetic Engineering News