Drs. Erik De Clercq and Anthony S. Fauci win 2010 Dr. Paul Janssen Award for Biomedical Research
Recognized for pioneering work in understanding and combating HIV/AIDS
9-Sep-2010 - Johnson & Johnson today announced that Erik De Clercq, M.D., Professor Emeritus, Rega Institute
for Medical Research, Leuven, Belgium, and Anthony S. Fauci, M.D., Director of the National Institute of Allergy and Infectious Diseases, the National
Institutes of Health, Bethesda, MD, have been named the recipients of the 2010 Dr. Paul Janssen Award for Biomedical Research by an independent
selection committee comprised of world-renowned scientists.
The Dr. Paul Janssen Award salutes the most passionate and creative scientists in basic or clinical research whose scientific
achievements have made a measurable impact on human health. Drs. De Clercq and Fauci were selected for their pioneering work in understanding and
combating viral diseases, particularly HIV/AIDS. The Award, which includes a $100,000 shared prize, will be presented to the winners during a
ceremony in Washington, D.C., today. The award presentation and winners' speeches may be viewed live beginning at 9:00 a.m. via www.pauljanssenaward.com.
While accepting the honor, Dr. Fauci has declined his portion of the prize in order to comply with government ethics rules.
Johnson & Johnson will donate his portion of the prize money to two organizations: Partners In Health-an international non-governmental organization
dedicated to delivering quality health care to people and communities devastated by the joint burdens of poverty and disease, and Us Helping Us,
People Into Living, Inc. - one of the largest nonprofit black AIDS organizations in metropolitan Washington, D.C.
"Dr. De Clercq is a pioneer in the development of antiviral drugs which have saved the lives of millions of patients
infected with HIV and other viral diseases," said Solomon Snyder, M.D., Distinguished Service Professor of Neuroscience, Pharmacology and
Psychiatry, Johns Hopkins School of Medicine and Chairman, Janssen Award Selection Committee. "Dr. Fauci's many contributions to research
on the pathogenesis and treatment of immune-mediated diseases were transformative to our current understanding of the immune response and
the pathogenesis of HIV/AIDS."
Following today's award ceremony at the Ronald Reagan Building and International Trade Center in Washington, D.C., a panel of scientific HIV/AIDS experts
will join the winners to discuss the future of HIV research and the opportunities for its maximum impact on the global epidemic. An additional ceremony
will be held in Beerse, Belgium, on September 9, 2010.
"Scientific knowledge has advanced tremendously since HIV was first identified in early 1980s," said Paul Stoffels, M.D., global head,
Pharmaceuticals Research & Development, Johnson & Johnson. "At the time, HIV was a disease with very high mortality rates. While many
challenges remain, the breakthroughs led by scientists including Drs. De Clercq and Fauci are helping people with HIV to live long and productive lives."
"The passion with which these two scientists have both pursued and advanced scientific understanding to ultimately benefit patients reflects the
kind of leadership and innovation that defined Dr. Paul," said Harlan Weisman, M.D., Chief Science and Technology Officer, Medical Devices &
Diagnostics, Johnson & Johnson.
During his distinguished career, Dr. De Clercq played a leading role in the discovery of antiviral agents now used to treat a variety of
viral infections, including those caused by herpes simplex, varicella-zoster, cytomegalovirus, hepatitis B and HIV. Dr. De Clercq pioneered the
discovery of several antiviral agents which are approved for clinical use, directly impacting the lives of countless patients living with
HIV/AIDS and other viral diseases. In a joint effort between the research teams of Dr. Paul Janssen and Dr. De Clercq, the first NNRTIs
(non-nucleoside reverse transcriptase inhibitors) were discovered as a new strategy for the treatment of HIV infections, now a
critical and central component of many HIV treatment regimens.
"In working with Dr. Paul on the discovery of the first NNRTIs I always admired his drive for new scientific discoveries and his passion
for helping patients," said Dr. De Clercq. "Dr. Paul was a highly respected scientist whose work continues to extend and improve the lives of
people around the world, and I am honored to be selected as the recipient of an award whose namesake carries on his tremendous legacy."
Dr. Fauci has made significant contributions to the understanding of virtually every aspect of HIV pathogenesis over the past 29 years.
He pioneered the field of human immunoregulation with a number of scientific observations that serve as the basis for current understanding of the
regulation of the human immune response. He is widely recognized for delineating the precise modulation mechanisms of immunosuppressive agents.
He has made seminal contributions to the understanding of how the AIDS virus destroys the body's defenses and he has been instrumental in
developing highly effective strategies for treating people living with HIV.
"It's wonderful to do impactful, meaningful work that you love," said Dr. Fauci. "While we should be proud of the many
scientific advances that have been made in the fight against HIV/AIDS, we know that in many respects, our work is just beginning. Developing HIV
interventions and delivering them to the people who need them will require scientific and public health vision, and dedication from all sectors
About The Dr. Paul Janssen Award for Biomedical Research
Known to his colleagues as "Dr. Paul," Janssen was one of the 20th century's most gifted and passionate researchers. He helped save millions
of lives through his contribution to the discovery and development of more than 80 medicines, four of which remain on the World Health
Organization's list of essential medicines. The Dr. Paul Janssen Award for Biomedical Research was established by Johnson & Johnson
to honor the memory of Dr. Paul. Past winners include Craig Mello, Marc Feldmann, Sir Ravinder Maini, and Axel Ullrich. Learn
more at www.pauljanssenaward.com.
About the Selection Committee
The Dr. Paul Janssen Award independent Selection Committee is composed of some of the world's leading scientists, including National Medal
of Science winners, Nobel Laureates, members of the National Academy of Sciences and past winners of The Dr. Paul Janssen Award. The 2010
Selection Committee includes:
- Solomon Snyder, M.D., (chairman) distinguished service professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins School of Medicine; co-winner, 1978 Albert Lasker Award; winner, 2003 National Medal of Science (United States)
- Mary-Claire King, Ph.D., American Cancer Society Professor of Medicine and Genome Sciences, University of Washington, Seattle; member, National Academy of Sciences; member, American Academy of Arts and Sciences
- Robert S. Langer Jr., ScD, David H. Koch Institute Professor, Massachusetts Institute of Technology; 2006 National Medal of Science winner; Charles Stark Draper Prize winner, 2008 Millennium Prize winner; member, National Academy of Engineering, National Academy of Sciences, Institute of Medicine
- Jean Marie Lehn, Ph.D., professor, College de France; winner, 1987 Nobel Laureate in Chemistry (France)
- Craig Mello, Ph.D., professor, Molecular Medicine, University of Massachusetts Medical School and investigator, Howard Hughes Medical Institute; 2006 Nobel Laureate in Physiology or Medicine; 2006 Dr. Paul Janssen Award for Biomedical Research winner
- Sir Richard Sykes, Ph.D., chair, National Health Service, London; former rector Imperial College London; former chief executive officer, GlaxoWellcome; fellow of the Royal Society; honorary fellow of the Royal Society of Chemistry and fellow of the Academy of Medical Sciences (United Kingdom)
- Axel Ullrich, Director, Department of Molecular Biology, Max Planck Institute of Biochemistry, Germany; winner, 2009 Dr. Paul Janssen Award for Biomedical Research, 2010 Wolf Prize winner.
- Huda Zoghbi, M.D., Professor, Baylor College of Medicine; Investigator, Howard Hughes Medical Institute; member, National Academy of Science and the Institute of Medicine; member, Lasker Award jury; E. Mead Johnson Award for Pediatric Research winner.
An estimated 33 million people were living with HIV in 2007. There were 2.7 million new HIV infections and 2 million AIDS-related deaths in 2007 . After decades of increasing mortality, the annual number of AIDS deaths globally has declined in the past two years, in part as a result of greater access to treatment.
The rate of new HIV infections has fallen in several countries, but globally these favorable trends are at least partially offset by increases in new infections in other countries. Globally, women account for half of all HIV infections-this percentage has remained stable for the past several years. Nearly 3
million people were receiving antiretroviral treatment in low- and middle-income countries at the end of 2007. This represents 31% of estimated global need and a 45% improvement over 2006.
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