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New study released on World AIDS Day measures HIV anti-retroviral regimens' safety and efficacy

Viral failure twice as common in patients with high viral loads given Epzicom when compared to those treated with Truvada

LOS ANGELES (Dec. 1, 2009) - A study in the New England Journal of Medicine released on World AIDS Day reports that viral failure, the point at which medication can no longer suppress the HIV infection, was twice as likely and happened sooner among patients initiating anti-retroviral therapy with high viral loads who were given Epzicom when compared to similar patients treated with Truvada.
IMAGE:  Eric Daar, M.D., is LA BioMed's principal investigator on a study comparing safety and effectiveness of anti-retroviral regimens in treatment of HIV.

The research team was led by several investigators including Eric Daar, MD, a principal investigator at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), and it enrolled 1,858 patients in a study conducted through the AIDS Clinical Trials Group. The study, A5202, examined the safety and efficacy of four once-daily anti-retroviral regimens as initial therapy for HIV-1 infection.

Among the 797 patients initiating therapy with higher viral loads (100,000 copies per milliliter or more), the researchers found that those given Epzicom (a combination of abacavir and lamivudine) had twice as many virologic failures as those given Truvada (a combination of tenofovir DF and emtricitabine) after a median of 60 weeks of treatment.

"The patients in the study all did quite well. But for those starting with high viral loads, there was a highly significant difference in outcomes that favored those given Truvada compared to Epzicom," said Dr. Daar. "As we mark Worlds AIDS Day this year, we can celebrate the fact that there are many effective therapeutic options for the treatment of HIV-infected individuals and much ongoing research, like this study, to further refine and optimize the management of this disease."

World AIDS Day has been held on Dec. 1 of every year since 1988 to raise awareness around the world about AIDS and HIV. The study released by NEJM on World AIDS Day 2009 reports on research in which patients were randomly assigned to receive one of four oral once-daily regimens. Those regimens included Epzicom or Truvada with either Sustiva (efavirenz) or Reyataz (atazanavir) plus Norvir (ritonavir).

The researchers checked on the patients' medical conditions at 4, 8, 16 and 24 weeks after they entered the trial - then every 12 weeks thereafter for the duration of the study. Among the research volunteers who initiated therapy with high viral loads, viral failure occurred in 57 patients receiving Epzicom and in 26 patients taking Truvada. The group of patients taking Epzicom also had a significantly shorter time to virologic failure and adverse events than did patients who received Truvada.

The researchers will continue to examine the relative safety and effectiveness of Epzicom and Truvada in those starting therapy with lower viral loads and for the two other medications in the study, Sustiva and the Reyataz with Novir combination.

"This study and others like it help guide physicians and their patients in determining the optimal therapy for each individual with the goal of providing the safest and most effective regimens possible," said Dr. Daar.

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About LA BioMed

Founded in 1952, LA BioMed at Harbor-UCLA Medical Center is one of the country's largest nonprofit independent biomedical research institutes. It conducts biomedical research, trains young scientists and provides community services, including childhood immunization and nutrition assistance. The institute's researchers conduct studies in such areas as cardiovascular disease, emerging infections, cancer, diabetes, kidney disease, dermatology, reproductive health, vaccine development, respiratory disorders, inherited illnesses and neonatology. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA. For more information, please visit www.LABioMed.org

 

CONTACT:

Laura Mecoy
Lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Source: EurekAlert
http://www.eurekalert.org/pub_releases/2009-12/labr-nsr112409.php


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