Tenofovir, Leading HIV Medication, Linked with Risk of Kidney Damage
Risk Remains After Drug Use Ends, Say Researchers, Who Call for Patient Monitoring
By Steve Tokar
February 10, 2012 - Tenofovir, one of the most effective and commonly prescribed antiretroviral medications for HIV/AIDS, is associated with a
significant risk of kidney damage and chronic kidney disease that increases over time, according to a study of more than
10,000 patients led by researchers at the San Francisco VA Medical Center and the University of California, San
The researchers call for increased screening for kidney damage in patients taking the drug, especially those with other
risk factors for kidney disease.
analysis of comprehensive VA electronic health records, the study authors found that for each year of exposure to tenofovir, risk of
protein in urine - a marker of kidney damage - rose 34 percent, risk of rapid decline in kidney function rose 11 percent and risk
of developing chronic kidney disease (CKD) rose 33 percent. The risks remained after the researchers controlled for other kidney
disease risk factors such as age, race, diabetes, hypertension, smoking and HIV-related factors.
For individual patients, the differences in risk between users and non-users of tenofovir for each year of use were 13 percent
vs. 8 percent for protein in urine, 9 percent vs. 5 percent for rapidly declining kidney function and 2 percent vs. 1 percent
for CKD. "However, these numbers are based on the average risks in our study population, and patients with more risk factors
for kidney disease would be put at proportionately higher risk," said principal
investigator Michael G. Shlipak , MD, MPH, chief
of general internal medicine at SFVAMC and professor of medicine and epidemiology and biostatistics at UCSF.
Patients were tracked for an average of 1.2 years after they stopped taking tenofovir. They remained at elevated risk for at least six
months to one year compared with those who never took the drug, suggesting that the damage is not quickly reversible, said
Shlipak. "We do not know the long-term prognosis for these patients who stop tenofovir after developing kidney disease," he cautioned.
Tenofovir: Q&A for Patients and Providers
Tenofovir, for Patients and
The implications for patients already on or starting antiretroviral therapy are "mixed," said Shlipak. "The best strategy right now is
to work with your health care provider to continually monitor for kidney damage. Early detection is the best way to determine when the
risks of tenofovir begin to outweigh the benefits."
Shlipak noted that HIV, itself, increases the risk of kidney damage, while modern antiretroviral treatments clearly reduce that overall
risk. "Patients need to be aware of their kidney disease risks before they start therapy, and this should influence the medications that
they choose in consultation with their doctor," he said. "For an otherwise healthy patient, the benefits of tenofovir are likely to
exceed the risks, but for a patient with a combination of risk factors for kidney disease, tenofovir may not be the right medication."
Tenofovir is used to decrease viral load and increase immune cell count in people infected with the virus. It is currently considered
the preferred first line treatment for HIV because of its potency, overall low toxicity, and convenience of dosing. It is sold under
a variety of names, by itself and in combination with other medications.
The study examined the medical records of 10,841 HIV-positive veterans in the national VA health care system who were new users of
antiretroviral therapy from 1997 to 2007. It was published electronically in the journal AIDS on January 9.
Lead author Rebecca Scherzer, PhD, a researcher and statistician at SFVAMC and UCSF, said that the observational study was the largest
and most conclusive indication so far of tenofovir's association with kidney damage. "There have been a number of previous, smaller
studies suggesting that this drug might be associated with kidney disease, but the results were mixed," she said. "Those studies
may have missed this association because they were too small, lacked appropriate lab data or excluded subjects with pre-existing
renal impairment or risk factors for kidney disease."
To be sure that tenofovir was the culprit, Scherzer and her colleagues looked for associations between 18 other antiretroviral
medications and the same three measures of kidney disease: protein in urine, rapid decline in function and progression to
CKD. None were associated with higher risk.
Shlipak noted that the study results are particularly strong because two of the risk factors - decline in function and CKD - indicate
kidney function, while protein in urine indicates physical damage to the kidney. "These are independent markers," he said. "To see the
same drug cause both types of kidney disease gives you a very objective signal that something real is happening here."
Shlipak emphasized that, despite tenofovir's association with progressive kidney disease, it is an important component of effective
antiretroviral therapy that may be required in many patients to control viral load.
The VA is the largest provider of HIV care in the United States, said Shlipak. "We could not have done this work without access to
the VA's system of electronic medical records," he said. "In particular, the data kept by the VA Clinical Care Registry, located at
the VA Palo Alto Health Care System, were essential to this study."
Co-authors of the study are Michelle Estrella, MD, of Johns Hopkins School of Medicine; the late Andy I. Choi, MD, MAS, of SFVAMC
and UCSF; Steven G. Deeks, MD, of San Francisco General Hospital; and Carl Grunfeld, MD, PhD, of SFVAMC and UCSF.
The study was supported by funds from the National Institutes of Health, the National Center for Research Resources, the American Heart
Association and the Department of Veterans Affairs, some of which were administered by the Northern California Institute for Research
NCIRE - The Veterans Health Research Institute - is the largest research institute associated with a VA medical center. Its mission is
to improve the health and well-being of veterans and the general public by supporting a world-class biomedical research program
conducted by the UCSF faculty at SFVAMC.
SFVAMC has the largest medical research program in the national VA system, with more than 200 research scientists, all of whom are
faculty members at UCSF.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education
in the life sciences and health professions, and excellence in patient care.
Source: University of California, San Francisco
"Reproduced with permission - University of California, San Francisco "
University of California, San Francisco