How sexual contacts with outsiders contribute to HIV infections within communities
4-Mar-2014- While a number of strategies can prevent and control HIV transmission and spread, their effective use depends
on understanding the sexual networks within and between communities. A paper published in this week's PLOS Medicine reports a detailed analysis with
surprising results from the Rakai district in Uganda, one of the most studied areas of the HIV/AIDS epidemic in Africa.
Mary K. Grabowski, from Johns Hopkins Bloomberg School of Public Health, led an international group of scientists in an effort to test the
hypothesis that most people who contract HIV outside their household are infected through sex with someone from their local community. However,
studying 46 communities within the Rakai district in Uganda, the researchers found that introductions of HIV from outside the community are
frequent and seem to contribute substantially to sustaining the HIV epidemic within the community. While the largest fraction of new
infections take place within a household, the majority of new infections outside of the household appear to be contracted by sexual
contact with partners from outside the community.
Some of the data rely on the accuracy of self-reported sexual partnerships, but the findings were consistent between three different
approaches the scientists used to examine the question. And while it is not known whether the situation in communities outside of Rakai is similar,
these results suggest that HIV infections by sexual partners from outside the community are common, and that HIV prevention campaigns need to look
Funding: This study was supported in part by funding from the Division of Intramural Research, NIAID, NIH; NIAID (R01 A134826,
K22 AI092150-01, and R01 A134265); NICHD (R01 HD 050180); NIMH (K23 MH086338); the World Bank STI Project, Uganda; the Henry M. Jackson
; the Fogarty Foundation (5D43TW00010); the Johns Hopkins Sommer Scholarship; the Bill & Melinda Gates Foundation (22006); and
the Bill & Melinda Gates Institute for Population and Reproductive Health at JHU. No funding bodies had any role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: JL and CB are members of the Editorial Board of PLOS Medicine . DC has acted as a consultant to Medimmune
on issues unrelated to HIV (influenza). The authors declare no other competing interests exist.
Citation: Grabowski MK, Lessler J, Redd AD, Kagaayi J, Laeyendecker O, et al. (2014) The Role of Viral Introductions in Sustaining
Community-Based HIV Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics, and Egocentric Transmission Models.
PLoS Med 11(3): e1001610. doi:10.1371/journal.pmed.1001610
The Role of Viral Introductions in Sustaining Community-Based
HIV Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics, and Egocentric Transmission Models
Johns Hopkins Bloomberg School of Public Health
Source: Inovio Pharmaceuticals, Inc.
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