Overall risk of birth defects appears low for women taking antiretrovirals during early pregnancy
10-Nov-2014 - Boston, MA - Among pregnant women infected with HIV, the use of antiretroviral (ARV) medications early
in pregnancy to treat their HIV or to prevent mother-to-child transmission of HIV does not appear to increase the risk of birth defects
in their infants, according to a new study led by Harvard School of Public Health (HSPH). It is one of the largest studies to date
to look at the safety of ARV use during pregnancy.
While the study found that overall risk was low--in keeping with previous research that has found ARV use in pregnancy to be generally
safe--the researchers did find that one ARV drug, atazanavir, was associated with increased risk of birth defects and they said it
should be studied further.
"This study suggests that the benefits of using ARVs during pregnancy still far outweigh the risks for HIV-infected women, although they
also indicate a need for continued monitoring," said Paige Williams, senior lecturer on biostatistics at HSPH and the study's lead author.
The study will appear online November 10, 2014 in JAMA Pediatrics .
While the use of combination ARV regimens among HIV-infected pregnant women has helped substantially reduce the number of HIV-infected
infants, there remain concerns about the safety of in utero exposures to these medications--particularly as newer drugs are approved and
as an increasing percentage of women become pregnant while already taking ARVs.
The researchers looked at first-trimester exposures to ARVs in a group of 2,580 HIV-exposed, uninfected children enrolled between 2007
and 2012 in an ongoing U.S. study that follows HIV-infected pregnant women and their children--the Pediatric HIV/AIDS Cohort Study
(PHACS) Surveillance Monitoring of ART Toxicities (SMARTT) study.
Few individual ARVs and no classes of drugs were associated with increased risk of birth defects, the researchers found. However, when
atazanavir was used by mothers during pregnancy, risk of birth defects appeared to increase by about two-fold, particularly
musculoskeletal and skin anomalies. Since most women receive a combination of three or more ARV drugs during pregnancy,
the researchers also looked at what other drugs were commonly used together with atazanavir. When atazanavir was
used with newer drugs, such as tenofovir or emtricitabine, the risk of birth defects remained higher, but there
was no significant elevation in risk when atazanavir was used with older ARV drugs like zidovudine or lamivudine.
"As World Health Organization 2013 ARV guidelines are implemented globally, an increasing percentage of women with HIV will be expected to
enter pregnancy already receiving ARVs. This heightens the need to identify optimal regimens based on their safety profiles as well as
their effectiveness in preventing HIV transmission," said Williams.
Senior author of the paper was D. Heather Watts of the Office of the U.S. Global AIDS Coordinator, U.S. Department of State; Cenk Yildirim,
statistical programmer for the Center for Biostatistics in AIDS Research (CBAR) at HSPH, also participated in the study.
Funding for the study came from the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from
the National Institute on Drug Abuse, the National Institute of Allergy and Infectious Diseases, the Office of AIDS Research, the
National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on
Deafness and Other Communication Disorders, the National Heart Lung and Blood Institute, the National Institute of Dental
and Craniofacial Research, and the National Institute on Alcohol Abuse and Alcoholism, through cooperative agreements
with Harvard School of Public Health (HD052102, 3 U01 314 HD052102-05S1, 3 U01 HD052102-06S3) and the Tulane
University School of Medicine (HD052104, 3U01HD052104-06S1).
"Congenital Anomalies and In Utero Antiretroviral Exposure in Human Immunodeficiency Virus-Exposed Uninfected Infants, Paige L. Williams,
Marilyn J. Crain, Cenk Yildirim, Rohan Hazra, Russell B. Van Dyke, Kenneth Rich, Jennifer S. Read, Emma Stuard, Mobeen Rathore,
Hermann A. Mendez, and D. Heather Watts, for the Pediatric HIV/AIDS Cohort Study, JAMA Pediatrics , online
Nov. 10, 2014, doi: 10.1001/jamapediatrics.2014.1889
Harvard School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders
and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and
students, we work together to take innovative ideas from the laboratory to people's lives--not only making scientific breakthroughs,
but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty
members at HSPH teach 1,000-plus full-time students from around the world and train thousands more through online and
executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized
as America's oldest professional training program in public health.
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Contact: Marge Dwyer
Harvard School of Public Health
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