Will women use microbicides to protect themselves against HIV?
19-Apr-2012 - PROVIDENCE, R.I. - Are women willing to use a vaginal gel to protect themselves against
HIV infection? Researchers at The Miriam Hospital say that is the million dollar question when it comes to developing products known
as microbicides that can prevent the sexual transmission of HIV.
Now the findings of a new study known as Project LINK could offer critical insight on user experience with topical
vaginal gels - information that could be used to develop microbicide products that optimize a woman's experience, ultimately
leading to more consistent use.
Miriam researchers, led by psychologist Kathleen M. Morrow, Ph.D., examined how the formulation of a
microbicide - particularly the properties and characteristics of the gel itself - relates to user experience. This
information was used to show the range of different sensations and experiences reported by women when they use vaginal gels.
The findings were presented on April 17 at the International Microbicides Conference in Australia.
"Adherence and acceptability have been major challenges so far with microbicides," said Morrow. "But if we can develop a
product that delivers an effective drug that reduces HIV infections and it's something that women can tolerate - if not enjoy - then
the microbicide will have a greater impact on the HIV epidemic."
"It's incredibly important that scientists and microbicide developers hear the voice of potential microbicide users so
they can use that information to make the best prevention products possible," she added. "That's how we will begin to have a fighting
chance at stemming the tide of HIV and AIDS."
Microbicides are compounds in various topical forms, such as gels, creams, films and rings, that deliver specific drugs
that protect against HIV and other sexually transmitted diseases. Although a safe and effective microbicide has not yet been identified,
a number of different microbicides are currently in development.
Half of the estimated 34 million adults worldwide living with HIV and AIDS are women. Women are twice as likely as men
to acquire HIV from unprotected sex, but they remain dependent on male cooperation to protect themselves from infection. Microbicides
represent an HIV prevention method that women can control, which could be critical in cultures where women may have less power to
say "no" to sex, have difficulties negotiating condom use with their partners, and are more likely to be subjected to
non-consensual sex. This need is especially urgent in Africa, where AIDS is the leading cause of death and women are
disproportionally affected by the disease.
As part of Project LINK, 204 participants experienced four gels, rated how each felt and indicated which formulation
they would prefer. Researchers found that preferences varied among the participants, and users' experiences seemed to impact the
product they chose, with different women choosing different products. For example, while some women preferred a thicker
consistency, others preferred gels that were more lubricating.
They found women do indeed have very specific experiences when using vaginal gels and they can discriminate between
different gels based on properties such as texture or consistency. These experiences also impacted women's preferred product choice.
Researchers were then able to use this information to develop tools to show the range of different sensations and experiences
reported by women when they use vaginal gels.
Morrow said these user sensory perception and experience measures could help predict which properties play a role in
the decision to use a product. That information could then be harnessed to design better microbicides that people will use
consistently, she added.
"There is no other research group that I know of that is taking this approach to both understand the user experience and
use that understanding to develop very specific biomedical HIV prevention formulations or devices," said Morrow. "It's not that such
experiences are not considered in the development of microbicides, but we are doing so very early in the process, before any
Project LINK is funded by the National Institute of Mental Health. Co-authors include Joseph L. Fava, Ph.D., Erna M. Kojic, M.D., and
Rochelle L. Rosen, Ph.D., of The Miriam Hospital; David Katz, Ph.D., of Duke University; Patrick Kiser, Ph.D., of the University of
Utah; and David Friend, Ph.D., of CONRAD.
Morrow's principal affiliation is The Miriam Hospital, a member hospital of the Lifespan health system in Rhode Island, and direct
financial and infrastructure support for this project was received through the Lifespan Office of Research Administration. Morrow is
also an associate professor of psychiatry and human behavior (research) at The Warren Alpert Medical School of Brown University.
Jessica Collins Grimes