. AIDS patients have nearly a seven-fold increased risk of malignancies of the stomach compared to the general population.
. Their risk of malignancies of the esophagus is almost three times higher than in the general population.
. In both organs, these results are mainly due to a dramatically increased risk of lymphomas, but risks are also increased for carcinomas.
April 4, 2011 - ORLANDO, Fla. - Among people with AIDS, the risk of stomach and esophageal malignancies is higher than among the general population, according to study results presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.
"People diagnosed with AIDS are living longer due to improved therapies. However, they are at increased risk of
developing a number of different cancers, including Kaposi's sarcoma and several lymphomas. The risk of stomach and esophageal cancers in
AIDS patients has not previously been fully evaluated," said E. Christina Persson, Ph.D., a postdoctoral fellow at the National Cancer
Persson and colleagues utilized data from the HIV/AIDS Cancer Match Study, a linkage of 15 U.S. population-based HIV/AIDS and cancer
registries with data from 1980 through 2007. The study included 600,000 men and women diagnosed with AIDS, of whom 1,166 developed
stomach malignancies and 240 developed esophageal malignancies.
Overall, people with AIDS had a 6.9-fold increased incidence of stomach malignancies compared to the general population. The risk was
increased 70 percent for stomach carcinomas, with similar increases for proximal (cardia) and distal (non-cardia) carcinomas. The risk
for stomach lymphomas was 36-fold higher.
The overall risk of esophageal malignancies was 2.7 times higher among people with AIDS than in the general population. Risk was increased
54 percent for squamous cell carcinomas, 101 percent for adenocarcinomas, and 261-fold for lymphomas of the esophagus.
Persson said that the increased lymphoma risk among patients with AIDS was expected, but the increased risk for carcinomas
is a new finding. Additionally, the size of this study allowed the researchers to look at carcinoma subtypes.
"This study is unique because of its large size, which allowed us to look more closely at the different histologic and
anatomic subsites of the tumors," said Persson. "It will be important for us to evaluate trends in risk over time, particularly in
the modern HIV treatment era."
This abstract was presented at an AACR press conference on Monday, April 4 at 11:00 a.m. ET in room W313 of the Orange
County Convention Center.
Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org
American Association for Cancer Research
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, the AACR is the world's
oldest and largest professional organization dedicated to advancing cancer research. The membership includes 33,000 basic,
translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States
and more than 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate
progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs.
It funds innovative, meritorious research grants, research fellowships and career development awards. The AACR Annual
Meeting attracts more than 18,000 participants who share the latest discoveries and developments in the field.
Special conferences throughout the year present novel data across a wide variety of topics in cancer
research, treatment and patient care. Including Cancer Discovery , the AACR publishes seven major
peer-reviewed journals: Cancer Research ; Clinical Cancer Research ; Molecular Cancer
Therapeutics ; Molecular Cancer Research ; Cancer Epidemiology, Biomarkers &
Prevention ; and Cancer Prevention Research . AACR journals represented 20
percent of the market share of total citations in 2009. The AACR also
publishes CR , a magazine for cancer survivors and their families, patient advocates, physicians and scientists.
In Orlando, April 2-6:(407) 685-4001
Source: American Association for Cancer Research
"Reproduced with permission - American Association for Cancer Research"
American Association for Cancer Research