NEWS RELEASE
Study highlights converging and diverging immune factors that may predispose people to HIV and HSV
BRIGHAM AND WOMEN'S HOSPITAL
7-NOV-2022 —Genital herpes, caused by the herpes simplex virus-2 (HSV-2), is a known risk factor for HIV acquisition: people infected with HSV are three times more likely to acquire HIV. But do HIV predictors and other risk factors in the immune system and cervical mucosa predispose people to acquiring HSV-2? To answer this question, investigators at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, analyzed longitudinal samples of cervical and serum biomarker levels for immune activation, before and after subjects acquired HSV-2. They found that altered levels of specific biomarkers in the mucosa and serum were associated with HSV-2 acquisition only, while others overlapped with biomarkers and combinations predictive of HIV-1 acquisition. This study helps highlight the converging and diverging factors predisposing one to both viral diseases.
“HSV-2 infections, which cause genital herpes, have a high global prevalence especially in regions of Sub-Saharan Africa that are at the center of the HIV pandemic, where as much as 80 percent of women are infected with HSV-2,” said corresponding author Raina Fichorova, MD, PhD, of the Department of Obstetrics and Gynecology. “By identifying molecular predictors of HSV-2 risk, we help provide targets for future development of preventive treatments.”
Read more in Sexually Transmitted Infections.
JOURNAL
Sexually Transmitted Infections
METHOD OF RESEARCH
Observational study
SUBJECT OF RESEARCH
People
ARTICLE TITLE
Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion
ARTICLE PUBLICATION DATE
14-Sep-2022
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Media Contact:
Haley Bridger
Brigham and Women's Hospital
hbridger@bwh.harvard.edu
Source: https://www.eurekalert.org/news-releases/970463
"Reproduced with permission - BRIGHAM AND WOMEN'S HOSPITAL "
BRIGHAM AND WOMEN'S HOSPITAL
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