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Prevalence of non-communicable diseases among people living with HIV at HIV Clinic of Kigali University Teaching hospital (CHUK), a cross-sectional study

Scientific Reports (2026Cite this article

Abstract

The introduction of highly active antiretroviral therapy prolonged the life span of PLWHIV and therefore; they live longer and develop chronic diseases, which are associated with ageing related Non-Communicable Diseases. The study aimed to assess the prevalence of non-communicable diseases and associated risk factors among people living with HIV infection at a Tertiary Hospital of Rwanda. A cross-sectional study was conducted to PLWHIV followed at the ambulatory HIV clinic of Kigali University Teaching hospital (CHUK) from August 2019 to Feb 2020, A systematic random sampling approach was used to select participants from the clinic registry. Social-demographic data, psychometric and clinical data were collected using structured questionnaire. Anthropometric and biochemical measurements were performed and results were recorded using Epidata and exported to SPSS for analysis. Logistic regression analysis was used to explore associated risk factors. A total of 222 participants were enrolled from a cohort of 2580 PLWH in care. The overall prevalence of NCDs was 36%. The most common condition was hypertension 22.5%), Diabetes mellitus 9.9%, renal impairment 9.9%, and dyslipidemia 3.2%. Among these NCDs, a high proportion were newly identified cases: 80% for hypertension, 41% for diabetes, and 54% for renal impairment. The most frequent comorbidities were hypertension with renal impairment (35% of comorbid cases), and hypertension with diabetes (30%). Factors independently associated with NCDs included Age above 65years [AOR: 8.3;95%CI:2.3–30, P < 0.001],; physical inactivity [AOR:2.1,95%CI:1.1–3.8, P = 0.013]; adverse drug reaction 50% [AOR:2.2; 95%CI: 1.2–4.1, P = 0.009]. Non- communicable diseases are highly prevalent in PLWHIV, with Hypertension, Diabetes, and renal failure being the most common. A substantial proportion of cases remained. Old age, Physical inactivity, and adverse effect to drugs were significant predictors of NCDs in this population. These findings highlight the need of integrating NCDs screening and management within HIV care services.

Abbreviations

CHUK:

Kigali University Teaching hospital

CKD:

Chronic kidney disease

CVD:

Cardiovascular diseases

DM:

Diabetes mellitus

HbA1C:

Glycated hemoglobin

HDL:

High Density Lipoprotein

HIV:

Human immunodeficiency virus

HIVAN:

HIV associated nephropathy

HTN:

Hypertension

LDL-C:

Low density lipoprotein cholesterol

NCD:

non communicable disease

NRTI:

Nucleoside reverse transcriptase inhibitors

Open MRS:

Open Medical Record System

PLWHIV:

People Living with HIV

SD:

Standard Deviation

SPSS:

Statistical Package for Social Sciences

TC:

Total Cholesterol

USA:

United States of America

VL:

Viral load

WHO:

World health organization

Author information

Authors and Affiliations

  1. University of Rwanda, Kigali City, Rwanda

    Sylvie Turikumwe, Dyna Nyampinga, Simeon Turatsinze, Marie Paul Mukantagengwa, Jean Paul Rwabihama & Leopold Bitunguhari

  2. Kigali University Teaching Hospital (CHUK), Kigali City, Rwanda

    Leopold Bitunguhari

  3. Health Builders, Kigali City, Rwanda

    Alexandre Dukundane

  4. School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda

    Sylvie Turikumwe

Corresponding author

Correspondence to Sylvie Turikumwe.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics approvals

This research was conducted by respecting ethical standards according to the Declaration of Helsinki (1964). The permission to conduct this study was obtained from the research and ethics committee of university of Rwanda [CMHS/IRB/129/2019] and University Teaching Hospital of Kigali [EC/CHUK/085/2019] and Institutional review board (IRB) [139/CMHS IRB/2019]. Data collectors out of health facilities of interest were trained on study participants’ rights, confidentiality and ethical norms. Written informed consents were obtained from all study participants before starting the interview, and data were anonymously collected. For participants aged below 18 years, informed consent was obtained from a parent and/or legal guardian in addition to the participant’s own assent. The privacy and confidentiality of the study participants were ensured throughout and after the study. No benefits for study participants. Study participants were informed that there was no risk of withdrawal from the study.

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Cite this article

Turikumwe, S., Nyampinga, D., Dukundane, A. et al. Prevalence of non-communicable diseases among people living with HIV at HIV Clinic of Kigali University Teaching hospital (CHUK), a cross-sectional study. Sci Rep (2026). https://doi.org/10.1038/s41598-026-57403-7

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  • Received15 October 2025

  • Accepted05 June 2026

  • Published11 June 2026

  • DOIhttps://doi.org/10.1038/s41598-026-57403-7


This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Source: Nature
https://www.nature.com/articles/s41598-026-57403-7


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